Infection with the dengue virus makes mosquitoes more sensitive to warmer temperatures, according to a new study led by researchers at Penn State University. The team also found that infection with the bacterium Wolbachia, which was recently used to control mosquito viral infections, also increased the heat sensitivity of insects. The findings suggest that while global warming may limit the spread of dengue fever, it may also limit the effectiveness of Wolbachia as a biological control agent.
“Dengue fever, potentially Fatal illness If no cure exists virusSpread by the bite of Aedes aegypti. The mosquito is also involved in the transmission of viruses that cause many diseases, including Zika fever, Chikungunya fever, and yellow fever, “said Elizabeth McGraw, a professor of biology at Penn State University. Climate changeBy 2050, this mosquito range is expected to overlap with 50% of the world’s population, dramatically increasing the number of people who may be exposed to these viruses. “
In recent years, research groups around the world have tried to control these viruses by infecting Ae. Releases Aedes aegypti and Wolbachia pipientiis bacteria, mosquito McGraw explained that he had blended into the environment.
“Wolbachia has been shown to prevent viruses, including dengue fever, from replicating inside mosquitoes,” she said. “Importantly, Wolbachia is an approach that is inherited by mosquito offspring, self-propagating mosquitoes and reducing maintenance. Disease management on site. “
McGraw said that both the dengue virus and Wolbachia infect various tissues throughout the mosquito’s body and are non-toxic but cause an immune stress response.
“Mosquitoes infected with the dengue virus and Wolbachia are already suffering from stress reactions, so I thought they weren’t equipped to deal with additional stressors such as fever,” she said.
To investigate the effects of heat on dengue and Wolbachia-infected mosquitoes, the team placed the infected mosquitoes in sealed vials and submerged the vials in a water bath heated to 42 ° C. This is the extreme temperature that mosquitoes can encounter in the wild. The researchers then measured the time it took for the mosquitoes to become immobile and compared them to uninfected control mosquitoes.Their findings will be published in the journal today (July 22nd) PLOS neglected tropical disease..
“After a lot of trial and error, we were able to successfully adapt the heat-based physiological assay commonly used in Drosophila. [a model fruit fly species] To investigate the effects of both dengue virus and Wolbachia infections on heat susceptibility in our mosquito species. “
The team found that mosquitoes infected with the dengue virus were more susceptible to heat. When I put it in a bath, I got stuck almost three times as fast as an uninfected mosquito. Similarly, mosquitoes infected with Wolbachia were immobilized four times faster than uninfected mosquitoes.
Interestingly, according to Ware-Gilmore, the two drugs, dengue virus and Wolbachia, had no additive effect on mosquito heat resistance.
“Mosquitoes infected with both the dengue virus and Wolbachia may be expected to get stuck even faster than mosquitoes infected with only one of the microorganisms, but no additive effect was found,” she said. Said. “But the first indication that viral infections can affect the heat resistance of mosquitoes is to reduce mosquito survival, especially during exposure to mosquitoes. High fever.. And there are some known interactions between fever and Wolbachia, especially at the immature stage, which is also the first indication that adult-infected mosquitoes have reduced survival during heat stress. It’s a study. “
Ware-Gilmore shows that future climate models show an increasing frequency of extreme temperature events, with short-term exposure to high temperatures. Dengue fever Mosquitoes infected with Wolbachia.
“At low temperatures, we know it Dengue virus It may not be able to replicate fast enough to pass through the mosquito’s body, which reduces the risk of transmission, “she said. It acts as a counter-force to mosquito survival and may help reduce infections and potentially human disease outbreaks in hotter, more climate-changing areas. Similarly, our study suggests that Wolbachia may not function as a biological control agent in hotter areas, given its impact on mosquito survival. “
The study is published at PLOS neglected tropical disease..
Indonesian dengue research gives hope to the fight against illness
PLOS neglected tropical disease, journals.plos.org/plosntds/art… journals.pntd.0009548
Pennsylvania State University
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